Endocrine Abstracts

Decamethylcyclopentasiloxane (D5) is one of the most common chemical ingredients for daily necessities that can be absorbed through the skin, aerosol, or even orally. People are exposed to D5 daily, but the risk of prenatal exposure to D5 is not completely understood. In this study, the effects of prenatal exposure to D5 on neural development were assessed through behavioral tests on offspring mice. First, the developmental neurotoxicity test (DNT) was performed to determine i...

Butylparaben is an endocrine disrupting chemical (EDC) which is used as antimicrobial preservative in many cosmetic products. EDCs are structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases such as obesity, type 2 diabetes, and neurodevelopmental disease. Present study investigated that whether exposure to butylparaben during maternal pregnancy could cause the offspring’s neuronal development disorder. In vitro stu...

In our daily life, humans are exposed to lots of chemicals. Among those chemicals, octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) have been widely used in cosmetics for their functions such as softening, wetting, and viscosity control. However, the effect of these chemicals on the female reproductive systems has not been clearly elucidated. In the case of D4, it was recently recognized as an endocrine disrupting chemical (EDC), but the effect of D5 has...

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular, this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste an...

The chemically induced disturbance during the neurodevelopment stage could cause a serious disease. In vivo study is useful to discriminate against neurotoxic substances but is time-consuming and ethically problematic. So, we have previously established, developmental neurotoxicity test (DNT) in vitro method using Sox1-GFP. In this study we aimed to increase the predictability of discriminant function. The equation was statistically improved using thirty addi...

Decamethylcyclopentasiloxane(D5) is one of the most common chemical ingredient for cosmetic products, cleansing agents, hairdye, dry cleaning solvent and personal hygiene supplies. D5 is also known as estrogenic chemical. It can be absorbed through skin, airosol, and even oraly. People are exposed to D5 in daily environment. However, the risk of prenatal exposure to D5 has not yet been fully understood. Recent research shows that imbalance of dam’s estrogen induces brain ...

Mitochondria, which are essential organelles for endocrine health, plays an important role in various physiological functions including hormonal biosynthesis, cell metabolism, proliferation and differentiation. Thus, mitochondrial toxicity can affect a variety of organs, such as liver, heart, muscle, kidney, and central nervous system. Mitochondrial toxicity is recognized as a contributor to drug-induced toxicity of various drugs such as hydroxytamoxifen, valproic acid, acetam...

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...